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Boost Recovery With Predictive AI

Advanced tools — Predictive AI

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Rehab alone doesn’t work for everyone. Retorno uniquely offers an innovative solution based on predictive artificial intelligence (AI) that can sustain recovery and prevent relapse — even for people who have cycled from addiction to rehabilitation multiple times.

Addiction changes the brain

Drug and alcohol addiction changes the brain.

The addict’s brain becomes reliant on drugs or alcohol to trigger dopamine release. The brain learns to associate substance abuse with a dopamine surge, even as the addiction damages the prefrontal cortex, which is responsible for decision-making, impulse control, and self-regulation.

So, we have a perfect storm. The brain calls out for drugs or alcohol for relief, while impaired executive function and elevated anxiety make it increasingly challenging to stay clean and sober. Our innovative solution leverages Predict.AI.

For many people, sustaining recovery requires rewiring the brain to undo the damage. It's not just a matter of willpower.

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tailored treatment

What is Predict.AI?

Preddict.AI is a unique software solution powered by an intelligent algorithm that enables individualized treatment based on the characteristics of each patient.
Epigenic changes

Addiction changes gene function

Taking drugs or abusing alcohol doesn’t change genetic makeup, but it does affect how genes function. Epigenetic changes to genes occur as a result of external environmental factors. Substance abuse drives epigenetic changes to genes.

All the elements of rehab that are so important,  including addressing underlying mental health issues, don’t address genetic behavior. That’s where predictive AI comes in.

Learn more about how Preddict.AI enables breakthrough treatment for addiction.

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reset brain changes

Undoing the damage

Treatment at Retorno with predictive AI seeks to support recovery by reprogramming the genes responsible for triggering the strongest cravings

The treatment program can “erase” the memory of drug addiction, thereby reducing the risk of relapse and supporting sustained recovery.

Retorno uses predictive artificial intelligence developed in Israel to tailor treatment individually and reset the changes to the brain, which can make sustained recovery so difficult.

customized treatment

How predictive AI works

Research led by Professor Gal Yadid of Bar Ilan University — with the involvement of Retorno — found that epigenetic changes in gene expression triggered by addiction could be reversed or subdued by carefully calculated doses of DHEA, a safe, over-the-counter supplement.

Predictive AI calibrates the dosing to the needs of each patient during the treatment period.  Calibration is based on multiple parameters, including changing dopamine levels. The result is a dose customized and tailored for each person, with dosages adjusted throughout treatment according to measurable indicators.

Not a psychiatric medication

DHEA is a natural supplement available over-the-counter in the United States and other countries.

The Predictive AI program at Retorno operates under license by the Israeli Ministry of Health and is supervised by the Ministry of Health and the psychiatric, medical, and mental health professionals on staff at Retorno.

Dosing is calculated for each individual using Preddict.ai, a software platform developed in Israel, based on the research of Professor Gal Yaid and the Laboratory of Neuropsychopharmacology in the Multidisciplinary Brain Research Center at Bar-Ilan University. The staff at Retorno has been intimately involved in the development of Predict.AI.

What to expect in treatment?

DHEA, in dosages calculated by predictive artificial intelligence, in parallel to mental health counseling and group support, substantially reduces the risk of relapse after rehabilitation. In addition, participants often gain confidence, build self-esteem, become less impulsive, and are more able to resist cravings.

A typical course of treatment with predictive artificial intelligence is three months. Participants often continue in the rehabilitation community for an additional period to address emotional issues that may have fueled substance abuse in the past. 

The boost to recovery rates is enabled by optimal dosing of DHEA based on age, gender, ethnicity, previous drug consumption, health background, weight, and psychological parameters. The software builds a personal profile for each patient, through which the caregiver can monitor the patient’s progress, manage the course of treatment, and even predict the length of treatment needed and the probability of relapse.

DHEA — therapeutic supplement in addiction treatment

DHEA is not a drug; it is a naturally occurring steroid produced in relatively high abundance. Its natural production peaks at age 25 and then begins to decline. DHEA has been shown to increase energy, improve mood and well-being, and decrease depression and anxiety.

Unlike other pharmaceutical interventions for addiction, such as methadone, DHEA makes actual changes in the brain and only requires short-term treatment.

Retorno’s DHEA program based on predictive AI

Retorno offers individually tailored doses of DHEA, calculated by predictive analytics, as an option for clients in rehabilitation.

The positive effects on stress and mood, two major players when it comes to the drive to use substances again after recovery, are likely central to DHEA’s effectiveness. Many people use substances as a way of controlling their mood and coping with stress. DHEA makes it easier to stay on track and to feel good during and after recovery.

Get help today

Retorno partners with Predict.AI to provide a physician-guided DHEA supplement program during treatment. Success rates have been very encouraging.

Contact us today to learn how we can help you boost recovery success.

References

  1. Ahdoot-Levi, H., Croitoru, O., Bareli, T., Sudai, E., Peér-Nissan, H., Jacob, A., … & Yadid, G. (2021). The effect of dehydroepiandrosterone treatment on neurogenesis, astrogliosis and long-term cocaine-seeking behavior in a cocaine self-administration model in rats. Frontiers in Neuroscience, 15, 773197.
  2. Bilaus, B., Turchinski, N. R., Ahdoot, H. L., Gavish, R. E., Shany, O., Maayan, R., … & Admon, R. (2023). The Effect of Dehydroepiandrosterone Administration during Rehabilitation on White Matter Integrity Among Individuals With Polysubstance Use Disorder. Journal of Addiction Medicine, 10-1097.
  3. Ohana, D., Maayan, R., Delayahu, Y., Roska, P., Ponizovsky, A. M., Weizman, A., … & Yechiam, E. (2016). Effect of dehydroepiandrosterone add‐on therapy on mood, decision making and subsequent relapse of polydrug users. Addiction biology, 21(4), 885-894.
  4. Núñez, C., Zlebnik, N. E., Guillem, K., & Yadid, G. (2022). Hadas Ahdoot-Levi1†, Ofri Croitoru1†, Tzofnat Bareli1, Einav Sudai1, 2, Hilla Peér-Nissan1, Avi Jacob1, Iris Gispan1, Rachel Maayan3, Abraham Weizman3, 4 and Gal Yadid1, 2. Unraveling Vulnerability Factors in Addiction Drug Use and Potential Treatments.
  5. Vinson, G. P., & Brennan, C. H. (2013). Addiction and the adrenal cortex. Endocrine connections, EC-13.
  6. Yadid, G., Ahdoot-Levi, H., Bareli, T., Maayan, R., & Weizman, A. (2018). Dehydroepiandrosterone and Addiction. In Vitamins and hormones (Vol. 108, pp. 385-412). Academic Press.
  7. Yadid, G., Sudai, E., Maayan, R., Gispan, I., & Weizman, A. (2010). The role of dehydroepiandrosterone (DHEA) in drug-seeking behavior. Neuroscience & Biobehavioral Reviews, 35(2), 303-314.
  8. Yarowsky, M. (2015, July 26). Revolutionary: Israeli researcher says he can ‘erase’ memory of addiction. Retrieved from http://nocamels.com/2015/07/israeli-researcher-erase-memory-of-addiction/

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